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KMID : 0362720160540040274
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Journal of the Korean Dental Association
2016 Volume.54 No. 4 p.274 ~ p.283
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Contemporary Concept for Prevention and treatment of MRONJ (Medication Related Osteonecrosis of Jaw)
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박정현:Park Jung-Hyun
김선종:Kim Sun-Jong
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Abstract
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Bisphosphonates are widely used mainly for the treatment of osteoporosis and bone metastasis of malignancy. Since the first report of MRONJ, there have been many studies associated, however the pathogenesis of MRONJ is not yet clear. Medicationrelated osteonecrosis of the jaws (MRONJ) is a serious complication associated with long-term medication therapy. It is characterized by exposed necrotic bonein the jaw, which has persisted for more than 8weeks despite continuous treatment by dentist. The mechanism of development of MRONJ is still unclear and there is no definitive standard treatment for MRONJ. The purpose of this study is to investigate the jaw bone destruction mechanism of accumulated bisphosphonates, so that we can develop therapeutic method to repair the defect and stop the destruction process. The authors performed simultaneous application of PRF(Platelet rich fibrin) and BMP-2(Bone morphogenetic protein-2) to stimulate not only soft tissue healing but also osseous regeneration. Our case series demonstrate that simultaneous application of platelet rich fibrin and bone morphogenetic protein-2 can be a treatment of choice for MRONJ.
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KEYWORD
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Bisphosphonate, Osteonecrosis of the jaw, Bone morphogenetic proteins, Platelet rich fibrin, Regeneration
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